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KMID : 0360419690050020013
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Korean Journal of Pharmacology
1969 Volume.5 No. 2 p.13 ~ p.18
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The Effects of Diphenylhydantoin and Several other Agents Acting on CNS on the QO₂ and Non-inulin Space Na^(+), K^(+) Concentration in Cerebral cortcial Slices of Rat
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Abstract
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The effects of dephenylhydantoin, strychnine, coramine, d-amphetamine and chlorpromazine on ??O₂ and non-inulin space Na^(+), K^(+) concentration of rat cerebral cortical slices incubated in pH 7.4 glycylglycine glucose saline was investigated.
In general, there are decreased non-inulin space Na^(+) concentration or increased non-inulin space K^(+) concentration or both when the ratio of respiration to non-inulin space is greater than control group except in case of chlorpromazine 10^(-4) M. And it is suggested that the ratio of respiration to non-inulin space is responsible more closely for the non-inulin space Na, K concentration than ??O₂ expressed per tissue wet weight.
Effects of diphenylhydantoin and several other agents on electrolytes and the electroshock seizure threshold are discussed.
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KEYWORD
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